A nine months old male child was brought to pediatric OPD with complaints of recurrent upper and lower respiratory tract infections and ear discherge and also episodes of watery diarrhoea. There was similar history of his maternal uncle who died at an early age. Gram staining of throat swab and stool examination was advised by the attending physician. Microbiological findings were: Pic 1. (Gram stain), Pic 2. (Stool microscopy)
What are the findings in PIc 1 and Pic 2?
What is the immunodeficiency disorder in the child?
Pic 1
Pic 2
The patient is having humoral immunodeficiency.
ReplyDeleteBruton Disease (X-linked Agammaglobulinemia)
The patient is having humoral immunodeficiency.
Bruton Disease (X-linked Agammaglobulinemia)
Failure of pre-B cells to differentiate into immature B cells in the bone marrow.
Due to absence of an enzyme called Bruton’s tyrosine kinase
Recurrent bacterial infections (e.g., Haemophilus influenzae, Streptococcus pneumoniae, or Staphylococcus aureus) leading to acute and chronic pharyngitis, sinusitis, otitis media, bronchitis, and pneumonia
Samrat Yadav (70)
DeleteThe patient is having humoral immunodeficiency.
ReplyDeleteBruton Disease (X-linked Agammaglobulinemia)
Failure of pre-B cells to differentiate into immature B cells in the bone marrow.
Due to absence of an enzyme called Bruton’s tyrosine kinase
Recurrent bacterial infections (e.g., Haemophilus influenzae, Streptococcus pneumoniae, or Staphylococcus aureus) leading to acute and chronic pharyngitis, sinusitis, otitis media, bronchitis, and pneumonia
Pic 1 indicates streptococcus pneumoniae infection (gram positive bacteria)
ReplyDeletePic 2 giardia lamblia (parasite)
This child is suffering from bruton disease. (X linked agammaglobulinemia). It is due to absence of an enzyme brutons tyrosine kinase involved in transformation of pre B cell into immature B cell. It causes complete absence of all types of immunoglobulins. It results in recurrent bacterial infections usually cleared by opsonization, eg. Haemophilus influenza, streptococcus pneumoniae, staphylococcus aureus.
Viruses that are usually cleared by antibodies eg. Enteroviruses
Parasites which are usually resisted by secretory ig A eg. Giardia lamblia.
Sakshi
Roll no.68
Pic 1- streptococcus pneumoniae gram positive bacteria
ReplyDeletePic 2 -giardiasis
This immunodeficiency disorder is Bruton disease ( x- link agammaglobulinemia).
The disease is not apparent till about six months of age due to the passive protection afforded by maternal antibodies.
It presents as recurrent serious infection with pyogenic bacteria, particularly with pneumococci, streptococci, meningococci, pseudomonas and H.influenzae.
SHAILENDRA KUMAR MADDESHIYA
ROLL NO-75
Pic1_Streptococcus pneumoniae gram +ve bacteria
ReplyDeletePic2_Giardia lamblia
Patient is having humoral immunodeficiency disease_ Bruton disease ( X-linked Agammaglobulinemia)
due to absence of an enzyme Bruton's tyrosine kinase
Pic 1- streptococcus pneumoniae ( gram positive bacteria)
ReplyDeletePic 2- giardia lamblia
The immunodeficiency disorder may be bruton's disease( x- linked agammaglobunemia).
In this disorder pre B cell can't diffenciate in to immature B cell due to absence of enzyme bruton's tyrosine kinase. This enzyme is x linked so this disease is primarily seen in males, and
As in case maternal uncle of patient have same symptoms as patient who died at an early age. ( Male child received x chromosome from mother).
In this disorder, only T Cell mediated responses are normal and antibodies are absent in body so there are more chances of recurrent bacterial infection that are cleared by antibody opsonization such as patient is suffered from recurrent upper respiratory tract infection and microbiological finding in throat swab is streptococcus pneumoniae ( pic 1) in gram staining.
There are more chances of parasitic infection that are usually resist by secretary antibodies as microbiological finding in stool microscopy is giardia lamblia ( pic 2) which is cause of watery diarrhoea in patient.
Pic1_Streptococcus pneumoniae.
ReplyDeletePic2_Giardia lamblia
Patient is having humoral immunodeficiency disease Bruton disease
due to absence of an enzyme Bruton's tyrosine kinase
This is Shweta Srivastava (82)
Deletepic 1 streptococcus pneumoniae pic 2 giardia lamblia patient is suffering from humoral immunodeficiency Bruton disease due to absence of Bruton tyrosine kinase
ReplyDeletePic1_Streptococcus pneumoniae.
ReplyDeletePic2_Giardia lamblia humoral immunodeficiency Bruton disease due to absence of Bruton tyrosine kinase enzyme. Surabhi Gaur ( roll no 89)
Pic 1 - streptococcus pneumoniae
ReplyDeletePic 2 - giardia lamblia
Patient is suffering from humoral immunodeficiency Bruton disease due to absence of Bruton tyrosine kinase.
Well done students
ReplyDeletePic 1- streptococcus pneumoniae
ReplyDeletePic 2- giardia lamblia
The immunodeficiency disorder may be bruton's disease.
Pic 1 indicates streptococcus pneumoniae infection (gram positive bacteria)
ReplyDeletePic 2 giardia lamblia (parasite)
This child is suffering from bruton disease. (X linked agammaglobulinemia). It is due to absence of an enzyme brutons tyrosine kinase involved in transformation of pre B cell into immature B cell. It causes complete absence of all types of immunoglobulins. It results in recurrent bacterial infections usually cleared by opsonization, eg. Haemophilus influenza, streptococcus pneumoniae, staphylococcus aureus.
Viruses that are usually cleared by antibodies eg. Enteroviruses
Parasites which are usually resisted by secretory ig A eg. Giardia lamblia.
Pic 1- streptococcus pneumoniae ( gram positive bacteria)
ReplyDeletePic 2- giardia lamblia
The immunodeficiency disorder may be bruton's disease( x- linked agammaglobunemia).
In this disorder pre B cell can't diffenciate in to immature B cell due to absence of enzyme bruton's tyrosine kinase. This enzyme is x linked so this disease is primarily seen in males, and
As in case maternal uncle of patient have same symptoms as patient who died at an early age. ( Male child received x chromosome from mother).
In this disorder, only T Cell mediated responses are normal and antibodies are absent in body so there are more chances of recurrent bacterial infection that are cleared by antibody opsonization such as patient is suffered from recurrent upper respiratory tract infection and microbiological finding in throat swab is streptococcus pneumoniae ( pic 1) in gram staining.
There are more chances of parasitic infection that are usually resist by secretary antibodies as microbiological finding in stool microscopy is giardia lamblia ( pic 2) which is cause of watery diarrhoea in patient.
Pic 1- streptococcus pneumoniae gram positive bacteria
ReplyDeletePic 2 -giardiasis
Patient is having humoral immunodeficiency disease Bruton disease
Pic 1- streptococcus pneumoniae gram positive bacteria
ReplyDeletePic 2 -giardiasis
Patient is having humoral immunodeficiency disease Bruton disease
Pic-1 Streptococcus pneumoniae- gram positive bacteria
ReplyDeleteNormal infection cause upper respiratory tract infection and otitis media bronchitis and pneumonia
Pic-2 Girdia lamblia
This both picture is secondary infection after 6 month age whe antibodies are depleate.
In case of humoral immunodeficiency (Bruton disease)
Characterized by failure of pre -B cell to differentiate in to immature B cellin the bone marrow.
Absence of B cell and plasma cell in the circulation.
Decrease all type immunoglobulin.
Synthesis of heavy chain without forming light chain.so secondary infection cause by many pathogen .
Pic-1 Streptococcus pneumoniae- gram positive bacteria
ReplyDeleteNormal infection cause upper respiratory tract infection and otitis media bronchitis and pneumonia
Pic-2 Girdia lamblia
This both picture is secondary infection after 6 month age whe antibodies are depleate.
In case of humoral immunodeficiency (Bruton disease)
Characterized by failure of pre -B cell to differentiate in to immature B cellin the bone marrow.
Absence of B cell and plasma cell in the circulation.
Decrease all type immunoglobulin.
Synthesis of heavy chain without forming light chain.so secondary infection cause by many pathogen .
Pic 1 streptococcus pneumoniae
ReplyDeletePic 2 giardiasis
Patient is suffering from humoral immunodeficiency disease called bruton disease
Mitali Mehrotra (roll no.45)
DeletePic 1- streptococcus pneumoniae gram positive bacteria
ReplyDeletePic 2 -giardiasis
Patient is having humoral immunodeficiency disease Bruton disease
Anubhav Agrahari
ReplyDeleteRoll-no15
Name: HIFZA NAFIS
ReplyDeleteRoll number: 34
Patient is suffering from humoral immunodeficiency disease Bruton disease.
Pic 1 shows gram positive bacteria streptococcus pneumoniae whereas Pic 2 shows Giardiasis.
Pic 1 - streptococcus pneumoniae
ReplyDeletePic 2 - giardia lamblia
Patient is suffering from humoral immunodeficiency Bruton disease due to absence of Bruton tyrosine kinase.
Shreya, 77
Pic 1 indicates streptococcus pneumoniae infection (gram positive bacteria)
ReplyDeletePic 2 giardia lamblia (parasite)
This child is suffering from bruton disease. (X linked agammaglobulinemia). It is due to absence of an enzyme brutons tyrosine kinase involved in transformation of pre B cell into immature B cell. It causes complete absence of all types of immunoglobulins. It results in recurrent bacterial infections usually cleared by opsonization, eg. Haemophilus influenza, streptococcus pneumoniae, staphylococcus aureus.
Viruses that are usually cleared by antibodies eg. Enteroviruses
Parasites which are usually resisted by secretory ig A eg. Giardia lamblia.
Shruti chauhan
Roll no.79
Pic 1 indicates streptococcus pneumoniae infection (gram positive bacteria)
ReplyDeletePic 2 giardia lamblia (parasite)
This child is suffering from bruton disease. (X linked agammaglobulinemia). It is due to absence of an enzyme brutons tyrosine kinase involved in transformation of pre B cell into immature B cell. It causes complete absence of all types of immunoglobulins. It results in recurrent bacterial infections usually cleared by opsonization, eg. Haemophilus influenza, streptococcus pneumoniae, staphylococcus aureus.
Viruses that are usually cleared by antibodies eg. Enteroviruses
Parasites which are usually resisted by secretory ig A eg. Giardia lamblia.
SAMRIDDHi GUPTA
ROLL NO. 71
Pic 1- streptococcus pneumoniae gram positive bacteria
ReplyDeletePic 2 -giardiasis
Patient is having humoral immunodeficiency disease Bruton disease
Vaishnavi Sharma
94
Patient is suffering from humoral immunodeficiency disease Bruton disease.
ReplyDeletePic 1 shows gram positive bacteria streptococcus pneumoniae whereas Pic 2 shows Giardiasis.
Vaishnavi sharma
94
Picture 1.Streptococcus pneumoniae (gram positive bacteria)
ReplyDeletePicture 2.Giardia lamblia (parasite)
Patient is suffering from bruton disease. It is due to absence of Burton's tyrosine kinase which is involved in transformation of pre B cell into immature B cell
Pic 1 indicates streptococcus pneumoniae infection( gram positive bacteria)
ReplyDeletePic 2 giardia lamblia( parasite)
The immunodeficiency disorder may be bruton's disorder
Anand kumar
Roll n- 07
Pic 1-Streptococcus pneumonia (gram positive bacteria)
ReplyDeletePic 2-Giardiasis
Patient is having humoral immunodeficiency disease bruton disease.
Pic 1 indicates streptococcus pneumoniae infection (gram positive bacteria)
ReplyDeletePic 2 giardia lamblia (parasite)
This child is suffering from bruton disease. (X linked agammaglobulinemia). It is due to absence of an enzyme brutons tyrosine kinase involved in transformation of pre B cell into immature B cell. It causes complete absence of all types of immunoglobulins. It results in recurrent bacterial infections usually cleared by opsonization, eg. Haemophilus influenza, streptococcus pneumoniae, staphylococcus aureus.
Viruses that are usually cleared by antibodies eg. Enteroviruses
Parasites which are usually resisted by secretory ig A eg. Giardia lamblia.
Roll no 11
DeleteHarsh Tiwari
ReplyDeleteRoll No 32
Picture 1- Streptococcus pneumoniae
Picture 2-Giardia lamblia
Diagnosis-Bruton disease, characterized by absence of enzyme bruton's tyrosine kinase which is involved in transformation of pre B cell into immature B cell
ReplyDeleteSAMRIDDHi GUPTA
ROLL NO. 71
The patient is having humoral immunodeficiency.
Bruton Disease (X-linked Agammaglobulinemia)
The patient is having humoral immunodeficiency.
Bruton Disease (X-linked Agammaglobulinemia)
Failure of pre-B cells to differentiate into immature B cells in the bone marrow.
Due to absence of an enzyme called Bruton’s tyrosine kinase
Recurrent bacterial infections (e.g., Haemophilus influenzae, Streptococcus pneumoniae, or Staphylococcus aureus) leading to acute and chronic pharyngitis, sinusitis, otitis media, bronchitis, and pneumonia
Aryaman singh
ReplyDeleteRoll no 18
Pic 1- streptococcus pneumoniae gram positive bacteria
Pic 2 -giardiasis
Patient is having humoral immunodeficiency disease Bruton disease
ReplyDeletePic 1 indicates streptococcus pneumoniae infection (gram positive bacteria)
Pic 2 giardia lamblia (parasite)
This child is suffering from bruton disease. (X linked agammaglobulinemia). It is due to absence of an enzyme brutons tyrosine kinase .It causes complete absence of all types of immunoglobulins.
It results in recurrent bacterial infections usually cleared by opsonization.
Viruses that are usually cleared by antibodies eg. Enteroviruses
Parasites which are usually resisted by secretory ig A eg. Giardia lamblia
Pic 1 - streptococcus pneumoniae
ReplyDeletePic 2 - giardia lamblia
Patient is suffering from humoral immunodeficiency Bruton disease due to absence of Bruton tyrosine kinase.
Name -- Arpit Bumb
Rollno. -- 17
Pic 1-streptococcus pneumonia
ReplyDeletePic 2-giardia lamblia
The child is suffering from burton disease which is due to absence of enzyme burton tyrosine kinase.
Hena Haleem
Roll no.33
The patient is having humoral immunodeficiency.
ReplyDeleteBruton Disease (X-linked Agammaglobulinemia)
Failure of pre-B cells to differentiate into immature B cells in the bone marrow.
Due to absence of an enzyme called Bruton’s tyrosine kinase
Recurrent bacterial infections (e.g., Haemophilus influenzae, Streptococcus pneumoniae, or Staphylococcus aureus) leading to acute and chronic pharyngitis, sinusitis, otitis media, bronchitis, and pneumonia